Drug Toxicity

Drug Toxicity

  • Clozapine
Aplastic Anemia
  • Chloramphenicol
    · NSAIDs
    · Benzene
Atropine-like Side Effects
  • Tricyclics
  • Doxorubicin
  • Daunorubicin
Cartilage Damage in children
  • Fluoroquinolones (Ciprofloxacin & Norfloxacin)
  • Quinidine
Coronary Steal Phenomenon
  • Dipyridamole
Corneal micro deposits
  • Amiodarone
  • ACE Inhibitors
Diabetes Insipidus
  • Lithium
Disulfiram-like effect
  • Metronidazole
    · Sulfonylureas (1st generation)
Extrapyramidal Side Effects
  • Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)
Fanconi’s Syndrome
  • Tetracycline
Fatal Hepatotoxicity (necrosis)
  • Valproic Acid
    · Halothane
    · Acetaminophen
Gingival Hyperplasia
  • Phenytoin
Gray Baby Syndrome
  • Chloramphenicol
  • Cimetidine
    · Azoles
    · Spironolactone
    · Digitalis
    · Estrogen & testosterone
    · INH & ethionamide
    · Clomiphine
    · Phenytoin
    · Reserpine & Methyldopa
Hand Foot Syndrome
  • 5-Flurouracil (5-FU)
Hemolytic Anemia in G6PD-deficiency
  • Sulfonamides
    · Isoniazid
    · Aspirin
    · Ibuprofen
    · Primaquine
Hemorrhagic Cystitis
  • Cyclophosphamide
    · Ifosamide  (Treat by Mesna & Acetylcysteine Bladder Wash)
  • Isoniazid
Hot Flashes, Flushing
  • Niacin
    · Tamoxifen
    · Ca++ Channel Blockers
Hypertension: Postural
  • Prazocin
Hypertension: Rebound
  • Clonidine withdrawal
Increased intra cranial tension ( ICT)
  • Amiodarone
    · Hypervitaminosis A
    ·  OCP’s
    ·  Tetracycline
    ·  Quinolones
Induce CP450
  • Barbiturates
    · Phenytoin
    · Carbamazepine
    · Rifampin
Inhibit CP450
  • Cimetidine
    ·  Erythromycin
    ·  Ketoconazole
    ·  Isoniazid (INH) [remember CEKI]
Interstitial Nephritis
  • Methicillin
    · NSAIDs (except Aspirin)
    · Furosemide
    · Sulfonamides
Milk Alkali Syndrome
  • Calcium Carbonate (CaCo3)
Monday Disease
  • Nitroglycerin Industrial exposure ® tolerance during week ® loss of tolerance during weekend ® headache, tach, dizziness upon re-exposure
  • Cephaloridine
    · Gentamycin
    · Amphotericin
Orange Body Fluids
  • Rifampin
  • Heparin
    · Corticosteroids
  • L-Asparginase
    ·  Glucocorticoids
  • Lomefloxacin
    · Pefloxacin
Positive Coombs’ Test
  • Methyldopa
Pulmonary Fibrosis
  • Bleomycin
    · Amiodarone
Rabbit Syndrome (Perioral tremors)
  • Phenothiazines
Red Man Syndrome
  • Vancomycin (rapid IV)
Severe HTN with Tyramine
  • MAOIs
SLE- Drug Induced
[Anti Histone Antibody Characteristic of this]
  • Chloropromazine
    · Hydralazine
    · Isoniazid
    · Methyldopa
    · Procainamide
    · Quinidine [ remember CHIMP -Q]
Tardive Dyskinesia
  • Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)
  • Aspirin
    · Quinidine
Torsades de Pontis
  • Terfanadine

October 16, 2010

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