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Diabetes drug may protect against cancer

Yesterday, I covered some of the key pathways and kinases associated with cell energy metabolism, LKB1 and AMPK.  These, together with Insulin-like Growth Factor-I (IGF-I) and the insulin receptor (IR), appear to play important roles in the broader regulation of energy and homeostasis.  Experimental evidence suggests that an overexpression of IGF-I is implicated in pancreatic tumours, for example. Increased IGF-II and decreased IGF binding protein (IGFBP)-3 serum concentrations have also been linked to a number of other cancers.

If we look at the IGF-IR pathway, we can see more clearly how they all interlink and how mTOR, LKB1 and AMPK may all be a critical part of the process:

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Nirbhay Patel

Business Manager - Sanofi India
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